This depends upon the nut that is being used with the screw. If you are using a KHD, VHD, WDG, or NTB nut it is not recommended to a grease because it can actually cause the nut to bind. If you are using a CMP, ZBX, XBA, BFW, or NTG nut, Lubriplate ES-DS has been tested to show that there is no negative impact on either the nut material or screw. There may be other lubricants out there that will work, but only the ES-DS has been tested by Haydon Kerk.